Canine olfactory ensheathing cells from the olfactory mucosa can be engineered to produce active chondroitinase ABC
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چکیده
منابع مشابه
Olfactory Ensheathing Cell Tumor Arising from the Olfactory Mucosa
We report a rare case of olfactory ensheathing cell tumor. A female presented a large soft mass extending medially to the olfactory cleft and laterally to the middle meatus in the left nasal cavity. Imaging studies confirmed a cystic mass extending superiorly into the frontal lobe, indicating that the tumor arouse from the olfactory mucosa. A subtotal resection was achieved through an endoscopi...
متن کاملIn vitro Maintenance of Olfactory Mucosa with Enriched Olfactory Ensheathing Cells
1Department of Biochemistry, King George’s Medical University, Lucknow-226 003, India 2Department of Pediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi221005, India 3Department of Orthopedic Surgery, King George’s Medical University, Lucknow-226 003, India 4Department of Transfusion Medicine, King George’s Medical University, Lucknow-226 003, India 5Department ...
متن کاملTransplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury
Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring SCI in dogs. However, the presence of chondroitin sulphate proteoglycans within the extracellular matrix of the glial scar can inhibit efficient axonal repair and limit the therapeutic potential of OECs. Here ...
متن کاملCNPase Expression in Olfactory Ensheathing Cells
A large body of work supports the proposal that transplantation of olfactory ensheathing cells (OECs) into nerve or spinal cord injuries can promote axonal regeneration and remyelination. Yet, some investigators have questioned whether the transplanted OECs associate with axons and form peripheral myelin, or if they recruit endogenous Schwann cells that form myelin. Olfactory bulbs from transge...
متن کاملProtective effect of adult olfactory ensheathing cells against 6-OHDA toxicity in PC-12 cells
Olfactory ensheathing cells (OEC) have been successfully used to stimulate the growth of injured fibers and to promote functional recovery within the injured adult CNS. These cells exhibit functional properties, which are known to be involved in axonal elongation. OEC express high level of growth factors including NGF, GDNF, BDNF and NT-3, which are known to play an important role in nerve rege...
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ژورنال
عنوان ژورنال: Journal of the Neurological Sciences
سال: 2016
ISSN: 0022-510X
DOI: 10.1016/j.jns.2016.06.011